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Introduction


Department of Pharmacology is a part of pre-clinical sciences division of University of Health Sciences which makes an integral link between basic medical sciences and clinical sciences. The department supports postgraduate programs (MPhil & PhD) by providing a highly interdisciplinary framework for individual and thematic training programs within both classical and newly emerging areas in the biomedical sciences. We have close ties with other departments within the university and its affiliated colleges and institutions. The department will coordinate and collaborate in training and research with other biomedical national institutions. We have established working linkages with international institutes including Chinese Academy of Sciences, China, Xi'an Jiaotong University, China and University of Queensland, Australia.

Objectives

  • To create new biomedical knowledge and to apply the insights gained form basic sciences studies for further advancement in therapeutics strategies
  • To provide solid understanding of basic Pharmacology and to prepare our postgraduates with up to date knowledge of subject
  • To provide the postgraduate students with research environment to improve their research skills
  • To enable them to pursue careers as independent scientists, Pharmacologists and as good research oriented teachers
  • To prepare the postgraduates for life time learning and problem solving skills

Working Facilities

The department has a well-equipped laboratory for training and research work in the field of Pharmacology. The presence of functional Cell-culture lab within the department enables the students of UHS to perform their in vitro experiments. For Molecular Pharmacological experiments we got PCR, Real Time PCR and ELISA.
Future Plans
  • To improve infrastructure and research facilities in Cell-culture lab.
  • To equip the department with such instruments useful for drug testing for providing the quality control services to Pharmaceutical industry
  • To get our students trained from foreign research institutes

Research Activities

  • Cell culture experiments
  • Molecular mechanisms/pathways involved in Inflammatory diseases
  • Mechanism of action of natural medicinal compounds/extracts
  • Development of disease models of animals
  • Pharmacogenetics
  • Pharmacognosy
  • Alternative Medicine
  • Pharmacological and adverse effects of medicinal compounds/extracts
  • The identification of the active principle of medicinal plants
Funded Research Projects
  • "Anti-Inflammatory Effect of Zingiber Officinale (Ginger) and Methylprednisolone on the mice Model of Allergic Airway Inflammation funded by Pakistan Science Foundation in 2010.
  • "Optimization of mtDNA Amplification system for Forensic Application funded by HEC Pakistan in 2012.
  • "Relationship of genetic and environmental factors with asthma in district Lahore funded by HEC Pakistan 2012.
  • "Anti-arthritic activity of N0-[(2,4-dihydroxyphenyl)methylidene]-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-1 (4H)-yl)acetohydrazide" funded by HEC Pakistan 2013.

Research Publications of Pharmacology

  1. Arham Shabbir, Muhammad Shahzad*, Akbar Ali, Muhammad Zia-ur-Rehman. Discovery of new benzothiazine derivative as modulator of pro- and anti-inflammatory cytokines in rheumatoid arthritis". Journal of inflammation (Accepted)
  2. Shazana Rana, Muhammad Shahzad*, Arham Shabbir. Pistacia integerrima ameliorates airway inflammation by attenuation of TNF-?, IL-4, and IL-5 expression levels, and pulmonary edema by elevation of AQP1 and AQP5 expression levels in mouse model of ovalbumin-induced allergic asthma. Phytomedicine. doi:10.1016/j.phymed.2016.04.006
  3. Arham Shabbir, Hafiza Maida Arshad, M Shahzad, Sadia Shamsi, Muhammad Imran Ashraf. Immunomodulatory activity of mefenamic acid in mice models of cell?mediated and humoral immunity. IJP. Vol. 48, Issue 2, (2016)172-178.
  4. M Shahzad, DM Small, C Morais, K Wojcikowski, GC Gobe. Protection against oxidative stress-induced apoptosis by angelica sinensis and astragalus membranaceusin human kidney proximal tubular cells. J Ethnopharmacol. 17;179:412-9. doi: 10.1016/j.jep.2015.12.027/li>
  5. Imran, M Shahzad*, Arham Shabbir. Oxyresveratrol ameliorates allergic airway inflammation via attenuation of IL-4, IL-5, and IL-13 expression levels. Cytokine 76 (2015) 375-381
  6. M Shahzad, Arham Shabbir, K Wojcikowski, Wohlmuth H , GC Gobe. The antioxidant effects of Radix Astragali (Astragalus membranaceus and related species) in protecting tissues from injury and disease. Curr Drug Targets. 2015 Sep 6. [Epub ahead of print]
  7. Ghulam Abbas, Muhammad Shahzad*, Zeb Saddiqe, M Jawad Hassan, Sumbal Saba, Jamal Rafique, Rizwana Malik, Hidayat Hussain. Various fractions of Hypericum x moserianum and Hypericum ericoides possess antiglycation, anti-lipid peroxidation, antioxidative activities and non-toxic effects in vitro. Pak. J. Pharm. Sci., Vol.28, No.3, May 2015, pp.933-938.
  8. Arham Shabbir, Muhammad Shahzad*, Glenda Gobe, Paul Masci. Protective activity of medicinal plants and their isolated compounds against the toxic effects from the venom of Naja (cobra) species. Journal of Ethnopharmacology. 157 (2014). 222-227.
  9. Arham Shabbir, Muhammad Shahzad*, Akbar Ali, Muhammad Zia-ur-Rehman. Anti-arthritic activity of N0-[(2,4-dihydroxyphenyl)methylidene]-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-1 (4H)-yl)acetohydrazide. European Journal of Pharmacology 738 (2014) 263-272.
  10. Khan AM, Shahzad M*, Raza Asim MB, Imran M, Shabbir A. Zingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune response. Pharm Biol. 2014 Nov 25:1-9.
  11. Muhammad Naeem Riaz, Muhammad Imran Sajid, Muhammad Shahzad, Imtiaz Majeed,Faheem A. Siddique, Nadeem Alvi, Irfan Bashir. An in vitro study on eugenia jambolanaplant extract in isolated rabbit ilium showing spasmolytic effects. Canadian Journal of Applied Sciences. 1(4): 01-17; January, 2014
  12. Ghulam Abbas, M. Jawad Hassan, Muhammad Shahzad, Javid Hussain, Shahida Parveen, Alya Maimoon. Non-Toxic Fractions of Hypericum perforatum and Hypericum oblongifolium Inhibit Protein Glycation, Free Radicals Production and Lipid Peroxidation in vitro. International Journal of Phytomedicine. 5(2013) 191-196
  13. Hongbo Li, Baoying Wang, Muhammad Shahzad, Chenghu Hu, Mingshu M, angying Du, Xiaorui Yu. 17?-Estradiol Impedes Bax-Involved Mitochondrial Apoptosis of Retinal Nerve Cells Induced by Oxidative Damage via the Phosphatidylinositol 3-Kinase/Akt Signal Pathway. J Mol Neurosci. 2013 Jul;50(3):482-93.
  14. Arham Shabbir, Muhammad Shahzad, Yasir Arfat, Liaqat Ali, Rao Salman Aziz. Berberis lycium Royle: A review of its traditional uses, phytochemistry and pharmacology. African Journal of Pharmacy and Pharmacology Vol. 6(31), pp. 2346-2353, 22 August, 2012
  15. Ghulam Abbas, Muhammad Shahzad, Muhammad Jawad Hassan, Rasool Bakhash Tareen and Muhammad Iqbal Choudhary. Antiglycation, Antioxidant and Anti Lipid Peroxidation Activities of Microcephala lamelatta With Low Cytotoxic Effects In vitro. Middle-East Journal of Scientific Research 11 (6): 814-818, 2012
  16. A. A. Albajali, A. H. Nagi, M. Shahzad, M. Ikram Ullah and S. Hussain. Effect of Allium sativa L. on pancreatic ?. cells in comparison to Nigella sativa L. in sreptozotocin induced diabetic rats. Journal of Medicinal Plants Research Vol. 5(24), pp. 5779-5784,2011.
  17. Khizar Hayat, Xudong Yang, Muhammad Shahzad, Li Miao, Lin Zhang. Fibrillin 3 Gene Mutation in Chinese Patients with Marfan syndrome. Pakistan J. Zool., vol. 43 (5), pp. 967-971, 2011..
  18. Hayat K, Shahzad M, Lin Z, Miao L, Xue S. Surgical therapy of unusual congenital corneal fibroma. J Ayub Med Coll Abbottabad. 2010 Jan-Mar;22(1):180-2.
  19. Soban Sadiq, Abdul Hannan Nagi, Muhammad Shahzad, Azam Zia. Reno Protective Effect of Aqueous Extract of Carum carvi (Black Zeera) seeds on Streptozotocin induced Diabetic Nephropathy in Rodents. Saudi J of Kidney Dis and Transplantation. 2010;21(6):1058-1065
  20. Raza Asim M B, Muhammad Shahzad, Xudong Yang. Suppressive effect of black seed oil on ovalbumin induced acute lung remodelling E3 rats. Swiss Med Wkly.2010;140:w13128.
  21. Adnan Jehangir, A. H. Nagi, M. Shahzad, Azam Zia. The hepato-protective effect of Cassia Fistula (Amaltas) leaves in isoniazid and rifampicin induced hepatotoxicity in rodents. Biomedica , 2010,26: 25 – 29
  22. Xudong Yang, Qingzhu Sun, M. B. Raza Asim, Xiaogang Jiang, Bo Zhong, Muhammad Shahzad, Fujun Hang, Yan Han, and Shemin Lu. Nitric Oxide in Both Bronchoalveolar Lavage Fluid and Serum Is Associated With Pathogenesis and Severity of Antigen-Induced Pulmonary Inflammation in Rats. Journal of Asthma, 2010;47(2):135-44
  23. Usman Tahir, Salma Iqbal Naik, Salma Rehman and Muhammad Shahzad. A quantitative analysis for the toxic pesticide residues in marketed fruits and vegetables in Lahore, Pakistan. Biomedica 2009, 25: 171-174.
  24. Zhong Bo, Wang Huilian, Muhammad Shahzad, Ning Qilan, Han Yan, Yang Xudong, Zhan fujun, Lu Shemin. Identification of differentially expressed genes in rat asthma model by suppression subtractive hybridization technology. J Zhejiang Unin. (Medical Sci), 2009, 38 (4) : 362-369.
  25. Congshan Jiang, Muhammad Shahzad, Liesu Meng. Housekeeping gene stability in pristane induced arthritis and antigen induced pulmonary inflammation of rats. Inflammation Research, 2009;58(9):601-9.
  26. Muhammad Shahzad, Xudong Yang, Raza Asim M B. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulmonary Pharmacology and Therapeutics, 2009;22(1): 37-43.
  27. I. Javed, Muhammad Shahzad. Effect of dipyrone on the renal clearance and urinary excretion of norfloxacin in sheep. Pakistan vet. Journal, 2005, 25 (4).

Staff



Prof. Naseem Saud Ahmad
  • Head of Pharmacology
  • Professor
  • M.B.B.S, M. Phil, Ph. D.
  • Ph: +9242-111 333 366 Ext: 308

Dr Muhammad Shahzad
  • Assistant professor
  • PhD (Xi’an Jiaotong University, China)
  • Post-doctorate (University of Queensland, Australia)
  • Post-doctorate (Chinese Academy of Sciences, China)

Amara Mehmood
  • Lab Manager / TRF

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