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Introduction


Overview of Department
The Department of Physiology & Cell Biology, an integral part of the basic medical sciences division at the University of Health Sciences, with a strong interdisciplinary approach, focuses on developing and delivering quality postgraduate programs. The Department provides an excellent environment for postgraduate studies, attempts to integrate molecular, cellular and systems approaches to physiological sciences. It also promote research interaction with public agencies and industry through outreach and scientific leadership; organize symposia, seminars and special lectures in relevant disciplines at national and international levels.

The Department offers PhD program and an MPhil program leading to PhD degree. The teaching in the department is committed to bring changes to the traditional teaching practices and takes full advantage of advanced audio-visual systems both in lectures and Lab exercises which include Power lab experiments. In additions to the regular teaching, the students regularly attend tutorials, journal club meetings and informal discussion on the topics that need further explorations. Every student is supposed to present latest papers/studies, published in international journals, and related to his/her thesis. Also, every student of the M.Phil. (primary) presents his/her hypothesis on which he/she is going to write their synopsis and when ready, at least, two presentations are given by the respective student which are discussed very extensively and new point arising out of these discussion are incorporated which increases the acceptability and scientific merit of the synopsis to be submitted to Advanced Studies and Research Board of the University. Similarly, the students of the final year keep on reporting on the results obtained during their research work and these are also discussed and ideas for explanation and discussion evolving during these discussions help the candidate a lot in presentation of the final thesis of the students. In order to give exposure to teaching and lab conduction, the final year students are involved in running the labs along with the faculty. This practice helps the students to hone and polish their skills in teaching and demonstrations.

The postgraduate program at UHS aspires to higher education and research training in selected areas of Physiology and Cell Biology. Specializations areas are:
  • Molecular and Cell Physiology
  • Metabolic Biochemistry
  • Systemic Physiology
  • Endocrinology
  • Reproductive and Developmental Biology
  • Environmental Physiology
Working Facilities

The Department has three well established Labs and centers namely Main Physiology Lab, Resource Lab for Molecular & Cell Biology and Centre of Research in Endocrinology and Reproductive Sciences. Currently, the laboratories are well-equipped with modern research facilities for DNA studies, proteomics, immunoassay, radioimmunoassay, DNA sequencing analysis, Karyotyping, and blood and tissue chemistry. Instruments like Immunofluorescence and inverted research microscopes, HPLC, bone profiler, Horizontal and Vertical electrophoresis, and biosafety laminar flow cabinets are continuously used for various research experiments.

The Department also possesses a good-sized departmental library.

Research Activities

Being an integral part for the award of MPhil and PhD degrees, all students undertake research in different fields of Physiology. Major research interest of Physiology & Cell Biology Department are:

  • Vitamin D Prevalence in Pakistani Population
  • Vitamin D association with different metabolic disorders
  • Vitamin D receptor genetics
  • Diabetes, Metabolic Syndrome and Insulin Resistance
  • PCOs and Endometriosis
  • Bone Health and Nutrition
  • COPD and Respiratory disorders
  • Reproductive Biology of Male Gamete
  • HCV Pathogenesis and related Physiological Issues
  • Dengue Infection and interaction with Host-genes
  • Ovarian cancer proteomics
  • Gestational Diabetes Mellitus
  • Myocardial infarction

Research funding

The research work performed at Department of Physiology is funded by different agencies like HEC, PMRC and PSF in addition to University of Health Sciences, Lahore.

1. Research Projects sponsored by Higher education commission, Pakistan (HEC)

  • Serum Somatostatin 1GF-1 and insulin Resistance in Patients of Polycystic Ovarian Syndrome and in Healthy Females of Rs 241,230/-
  • Correlation between homocysteine, Vitamin D, Vitamin B12, Folate and Bone Health in Postmenopausal Pakistani Women of Rs.762, 721/-
  • Serum Vitamin D Level and VDR polymorphism (Fok-1, and BSM-1) in type 1 Diabetics of local population of Rs.440,197/-
  • Arsenic and lead in serum and breast milk in female agricultural farm workers of Bahawalpur of Rs.294,847/-
  • Endometriosis and its association with TP53 gene (Codon 72) polymorphism in Lahore Rs.244,459/-
  • Comparative Study of Serum Anti-Citrullinated Protein Antibody and Rheumatoid Factor for Diagnosing Rheumatoid Arthritis Boys Rs.182541/-
  • Role of Anti-Cyclic Citrullinated Peptide Antibody and Anti-Mutated Citrullinated Vimentin Antibody in Diagnosing Rheumatoid Factor Negative Rheumatoid Arthritis Patients of Rs. 231621/-
  • Serum Vitamin D Level and VDR polymorphism (Fok-1, and BSM-1) in type 1 Diabetics of local population of Rs. 440197/-
  • A study of genetic variations in cytokines and TLRs genes and their expression level in association with dengue pathogenesis of Rs. 1763920/-

2. Projects sponsored by Pakistan Medical research council (PMRC)

  • Early Onset Of Renal Function Decline And Its Correlation With Serum Uric Acid In Diabetic Nephropathy of Rs. 48000/-
  • Serum Hyaluronic Acid as Biomarker of Disease Severity in Osteoarthritis Rs.48000/-
  • Effect of Breast and Bottle Feeding on Bone Growth in Prepubertal Children Rs.170,500/-

Seminars and workshops:

"Centre of research in endocrinology and reproductive sciences" at Department of Physiology & Cell Biology, University of Heath Sciences Lahore arranged a Seminar on 12 July, 2012. The seminar was entitled as "Vitamin D and Reproductive Health" by Professor Dr. Lubna Pal, Program Director Polycystic Ovarian syndrome/reproductive aging and bone. Yale Reproductive endocrinology Program, Yale University, USA.

Research Publications


Total of 36 research articles has been published, while 3 are submitted for publication in international research journals.

Year 2008

  1. SHAHID, A., LONE, K. P., SAEED, S. & ARSLAN, M. 2008. Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent. Hormones (Athens), 7, 313-319.
  2. Year 2009

  3. AKRAM, T., HASAN, S., IMRAN, M., KARIM, A. & ARSLAN, M. 2009. Association of polycystic ovary syndrome with cardiovascular risk factors. Gynecol Endocrinol, 26, 47-53.
  4. KARIM, A. & AFZAL, M. N. 2009. PUBERTAL DEVELOPMENT AND GROWTH AMONG BOYS IN A SAMPLE OF LOCAL PAKISTANI POPULATION. Acta Endocrinologica (Buc), 5, 165-174.
  5. MALIK, S., HANIF, A., KHOKHER, S., IQBAL, Z., RANA, S., IMRAN, M., BILAL, M. & ARSLAN, M. 2009. Association of genetic and non-genetic risk factors with specific BRCA mutation positive breast cancers in some Pakistani females. Pakistan Journal of Physiology, 5.
  6. SALEEM, M., TABASSUM, M. R., YASMIN, R. & IMRAN, M. 2009. Potential of xylanase from thermophilic Bacillus sp. XTR-10 in biobleaching of wood kraft pulp. International Biodeterioration & Biodegradation, 63, 1119-1124.

Year 2010

  1. AFZAL, S., SALEEM, M., YASMIN, R., NAZ, M. & IMRAN, M. 2010. Pre and post cloning characterization of a -1, 4-endoglucanase from Bacillus sp. Mol. Biol. Rep., 37, 1717-1723.
  2. Year 2011

  3. FATIMA, W., SHAHID, A., IMRAN, M., MANZOOR, J., HASNAIN, S., RANA, S. & MAHMOOD, S. 2011. Leptin deficiency and leptin gene mutations in obese children from Pakistan. Int J Pediatr Obes, 6, 419-427.
  4. HUSSAIN, A., BABAR, M. E., IMRAN, M., HAQ, I. U. & JAVED, M. M. 2011. Detection of four novel polymorphisms in PrP gene of Pakistani sheep (Damani and Hashtnagri) and goats (Kamori and Local Hairy) breeds. Virology journal, 8, 246.
  5. IMRAN, N., CHAUDRY, M. R., AZEEM, M. W., BHATTI, M. R., CHOUDHARY, Z. I. & CHEEMA, M. A. 2011. A survey of Autism knowledge and attitudes among the healthcare professionals in Lahore, Pakistan. BMC pediatrics, 11.
  6. RANA, S., WAHEED, I. & IMRAN, M. 2011. Specific post-transcriptional inhibition of mRNA for ligand binding chain of IgE high affinity receptor. Mol. Biol. Rep., 38, 675-681.
  7. ZAFAR, U., QURESHI, H. J. & KARIM, A. 2011. Insulin resistance and serum parameters of iron status in type 2 diabetics. Pak J Physiol, 7.

    Year 2012

  1. BABAR, M. E., HUSSAIN, T., IMRAN, M., NAGARAJAN, M. & KUMAR, S. 2012. Mitochondrial DNA diversity patterns in Pakistani buffalo. Animal genetics, 43, 315-317.
  2. BUGVI, S. M., IMRAN, M., MAHMOOD, S., HAFEEZ, R., FATIMA, W. & SOHAIL, S. 2012. Screening of intron 1 inversion and three intragenic factor VIII gene polymorphisms in Pakistani hemophilia A families. Blood Coagulation & Fibrinolysis, 23, 132-137.
  3. IMRAN, M., MAHMOOD, S., BABAR, M. E., HUSSAIN, R., YOUSAF, M. Z., ABID, N. B. & LONE, K. P. 2012. PRNP gene variation in Pakistani cattle and buffaloes. Gene, 505, 180-185.
  4. IMRAN, M., MAHMOOD, S., HUSSAIN, R., ABID, N. B. & LONE, K. P. 2012. Frequency distribution of PRNP polymorphisms in the Pakistani population. Gene, 492, 186-194.
  5. IMRAN, M., SAEED, M. T., MAHMOOD, S., MOHSIN, S., SOHAIL, S., MUNIR, A. & NAZIR, H. 2012. A strategy for carrier detection in Pakistani haemophilia B families. Haemophilia, 18, e348-e349.
  6. LONE, K. P., SAHAR, S. & FATIMA, S. 2012. Age-Related Changes in Ovarian Gross and Histological Characteristics During Pubertial Development in Captive Catla catla (Hamilton, 1822) of Age 18-29 Months. Pakistan J. Zool, 44, 159-172.
  7. MAHMOOD, U., IMRAN, M., NAIK, S. I., CHEEMA, H. A., SAEED, A., ARSHAD, M. & MAHMOOD, S. 2012. Detection of common mutations in the GALT gene through ARMS. Gene, 509, 291-4.
  8. SHAHID, A., SAEED, S., RANA, S. & MAHMOOD, S. 2012. Family history of diabetes and parental consanguinity: important risk for impaired fasting glucose in South East Asians. West Indian Medical Journal, 61, 219-223.

Year 2013

  1. ANSAR, T., TAHIR, M., LONE, K. P. & MUNIR, B. 2013. Immunolocalization of Aquaporin-10 in Tuberculous Human Ileum. Journal of the College of Physicians and Surgeons Pakistan, 23, 392-396.
  2. FAHEEM, M. & LONE, K. P. 2013. Acute toxicity and Behavioural response of Cirrhinus mrigala fingerlings to Bisphenol-A, 28-37.
  3. LIAQAT, I., JAHAN, N., LONE, K. P., PAKSTIS, A. & TAYLOR, H. S. 2013. Genetic polymorphisms associated with endometriosis in Pakistani women. Journal of Endometriosis, 5, 134-143.
  4. RANA, S., SHAHID, A., SAEED, S. & IQBAL, M. N. 2013. Comparison of Thyroid Function Tests by RIA/IRMA Based Commercial Kit and in House Method in Hypothyroid Patients. Annals of King Edward Medical University, 18, 180-190.
  5. SHAHID, A., RANA, S., SAEED, S., IMRAN, M., AFZAL, N. & MAHMOOD, S. 2013. Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females. BioMed research international,1.730, 01-08.
  6. SIDDIQI, H., TAHIR, M. & LONE, K. P. 2013. Variations in cerebral arterial circle of Willis in adult Pakistani population. J Coll Physicians Surg Pak, 23, 615-619.
  7. SARWAR, S., ASLAM, M., WAQAR, M. A., HUSSAIN M. AND BUTT I.F. 2013. Iodized Salt: A Risk Factor for Hyperthyroidism. J Rawal Med Col (JRMC)., 17(2):284-287.
  8. HAMEED, W., NAVEED, A.K. AND ASLAM, M. 2013. Effect of Visfatin on Testosterone Levels in Insulin Resistant Diabetic Male Sprague Dawley Rats. PAFMJ., 63(1): 29-33.

Year 2014

  1. GUL, A., LONE, K. P. & AHMED, A. 2014. Implications of umbilical cord blood serum in clinical applications. The Health, 4, 71-75.
  2. HUMAYUN, F., TAHIR, M., LONE, K. P., MUNIR, B., AHMAD, A. L. I. & LATIF, W. 2014. Protective Effect Of Ethanolic Extract Of Propolis On Isoniazid Induced Hepatotoxicity In Male Albino Mice. Biomedica, 30, 85-91.
  3. RANA, S., MUNAWAR, M., SHAHID, A., MALIK, M., ULLAH, H., FATIMA, W., MOHSIN, S. & MAHMOOD, S. 2014. Deregulated expression of circadian clock and clock-controlled cell cycle genes in chronic lymphocytic leukemia. Mol. Biol. Rep., 41, 95-103.
  4. ROOMI, M. A., LONE, K. P. & MADASSAR, A. 2014. Vitamin D and cardiometabolic risk factors in adult non-diabetic offspring of type 2 diabetic parents. J Pak Med Assoc, 64, 1229-1234.
  5. Year 2015

  6. SAEED, K., TAHIR, M., AND LONE, K.P. 2015. Effect of Phoenix dactyliferia (date palm) pit powder on nicotine induced spermatotoxicty in adult albino mice. J. Pak. Med. Assoc., 65: 43-48.
  7. ROOMI, M.A., FAROOQ, A., ULLAH, E. AND LONE, K.P. 2015. Serum vitamin D levels and the components of metabolic syndrome: an analytical cross-sectional study. Rawal Med. J., 40: 2-6.
  8. TUFAIL, R., AFZAL, N., JAVEID, K., SHAHZAD, F., KHALIQ, S., ABBAS, A., LATIF, W. AND TAHIR R. 2015. Percentage of T Cells in Diabetes Mellitus Patients Managed with different Treatment Modalities. SMU Med J., 2(1).
  9. NADEEM, A., MUMTAZ, S., NAVEED, A.K., ASLAM, M., SIDDIQUI, A., LODHI, G.M. AND AHMAD, T. 2015. Gene-gene, gene-environment interactions and single nucleotide polymorphisms of inflammatory cytokines. World J Diabetes 2015 Feb 11; online.
  10. JAVED K, AFZAL N, SHAHZAD F, ZAMAN S, KHALIQ S, JAHAN S, LATIF W, KHALIQ S. 2015. Increased frequency of HLA-DRB1*12 in asthma patients visiting a teaching hospital Lahore, Pakistan. International Journal of Current Research 7(4):14476-14480.

Faculty



Prof. Dr. Fridoon Jawad Ahmad
  • Head of Department
  • BS, Genetics (UW Madison, USA), PhD Cell & Molecular Biology, UW Madison, USA

Dr. Asima Karim
  • Associate Professor
  • MBBS (Pb), M.Phil. (UHS), Ph.D

Dr. Saba Khaliq
  • Associate Professor
  • M.Sc. (GCU), Ph.D. (Pb), Post-doc. (Germany)

Dr. Asma Salam
  • Lecturer
  • MBBS (Punjab), MS (Netherlands)
Laboratory Staff

Hafiz Usman Ahmad
  • Senior Lab Manager Quality Control Management
  • M.Phil. (MLS) Chemical Pathology Cont. University of Health Sciences Lahore

Ms. Rubina Sheikh
  • Senior Lab Technologist.
  • M.Sc. Molecular Biology & Biotechnology The school of Allied Health Sciences Medical Technology Laboratory Lahore
Supporting Staff

Qadeer-uz-Zaman
  • Department Assistant
  • Department of Physiology & Cell Biology, University of Health Sciences Lahore.

H.M. Nasir Ali
  • Office Helper
  • Department of Physiology & Cell Biology, University of Health Sciences Lahore.

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