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  • Introduction
  • Research Activities
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Introduction


Hematology deals with the diagnosis, treatment, and prevention of diseases of blood and bone marrow as well as of the immunologic, haemostatic (blood clotting) and vascular systems. Because of the nature of blood, the science of hematology profoundly affects the understanding of many diseases.

The Department of Haematology, is an integral part of the basic medical sciences division at the University of Health Sciences, with a strong interdisciplinary approach, focuses on developing and delivering quality postgraduate programs. The Department provides an excellent environment for postgraduate studies, attempts to integrate molecular,and cellular approaches to Hematological studies. The Department offers MPhil programme leading to PhD degree.

Working Facilities

Specializations: areas of teaching, training and research
  • Red cell disorders including
  • Nutrional Anemias
  • Haemoglobinopathies
  • Membranopathies
  • Benign and malignant White cell disorders
  • Myeloproloifeative Disorders
  • Stem cell transplantation
  • Hemostasis and Coagulation disorders
  • Thrombophilia
  • Transfusion Medicine
Teaching is based on:-
  • Lectures
  • Tutorials
  • Journal Club Discussions
  • Individual and Group Presentations
  • Seminars
  • Problem Based Learning (PBL)
  • Practical demonstrations
  • Morphology sessions
Facilities

The department has a well equipped laboratory for postgraduate practical training and research work in Haematology


Future Plans

Linkages will be developed with foreign institutions both for collaborative research and for short term training of personnel in specialized techniques and procedures in the field of Haematology and Transfusion Medicine.

Research Activities


Submitted Research Papers
  1. Antithrombin III as a Marker of Fibrosis in chronic Hepatitis C.
  2. Levels of platelet derived Microparticles and soluble P- selectin in patients of myocardial infarction.
  3. Frequency of Aspirin Resistance in Patients with coronary artery disease in Pakistan.
  4. Vkorc1 Gene Polymorphism (-1639g>A) and Warfarin Resistance in Patients on Warfarin Therapy.
  5. Mutations of FANCA gene in local population.
  6. Mutations of FANCC gene (IVS4+4 A>T, Del 322G, R548X) in local population.
  7. Effect of PAS on different in vitro parameters of random donor platelet concentrates during 10 days storage.
  8. Typing and Sub typing of vWD in local patients.
Completed Research Projects
  • Serum Hepcidin levels in Thalassemia Patients.
  • Serum Transferrin Receptors Levels in End Stage Renal Disease.
  • The frequency of BCR-ABL fusion gene in ALL in children and adults.
Ongoing Research Projects
  • Prevalence of Monoclonal Gammopathy of Undetermined Significance (MGUS) in Elderly.
  • Intron 1 inversion in Hemophilia A
  • Intron 22 inversion in Hemophilia A patients.
  • The frequency of TEL-AML1 fusion gene in ALL in children and adults.
  • Single Nucleotide Polymorphism of P2RY12 and CYP3A5 Genes in Clopidogrel Resistant Ischemic Heart Disease Patients.
  • Mutations of FANCG gene (313G?T and 307+1G?T) in patients of Fanconi Anemia in Local Population.
  • Role of CYP2C19 and PON-1 Polymorphisms in Clopidogrel Resistant Patients of Ischemic Heart Disease.
  • Mutations of FANCA gene (c.1115-1118delTTGG in exon 13 and c.3788-3790 Del TCT in exon 38) in patients of Fanconi anaemia in local population.
  • Comparison of Activated Partial Thromboplastin Time and Anti-Factor Xa Assay in Patients on Unfractionated Heparin Therapy.

Research Publications of Haematology

      Year 2015
    1. Faiza Yasmeen, Muhammad Bilal Ghafoor, Abdul Wadood Khalid, Waqas Latif, Shahida Mohsin, Shagufta Khaliq. Analysis of CYP2C9 polymorphisms (*2 and *3) in warfarin therapy patients in Pakistan. Association of CYP2C9 polymorphisms (*2 and*3) with warfarin dose, age, PT and INR.J Thromb Thrombolysis DOI 10.1007/s11239-015-1215-5.
    2. Zille Rubab, Huma Amin, Khizer Abbas, Shabbir Hussain, Muhammad Ikram Ullah, Shahida Mohsin. Serum Hepcidin Levels in Patients with End-Stage Renal Disease on Hemodialysis. Saudi J Kidney Dis Transpl 2015; 26(1):19-25.
      3. Year 2014
    3. Ayesha Bhalli, Tahir Saeed, Zille Rubab, Iram Aftab, Shabbir Hussain, Nabila Bashir and Shahida Mohsin. Protein C levels in chronic liver disease. Biomedica 2014; 30 ( 4) : 255-257.
    4. Massod M., Amin, H.,Abbas K., Mehmood S., Mohsin S. Nucleophosmin (NPM1) Gene 4-bp duplication in Pakistani patients with Acute Myeloid Leukemia. Biomedica 2014; 30(3):175-180.
    5. Rana S, Munawar M, Shahid A, Malik M, Ullah H, Fatima W, Mohsin S., Mahmood S. Deregulated expression of circadian clock and clock-controlled cell cycle genes in chronic lymphocytic leukemia. Mol Biol Rep.(2014) 41:95-103.
    6. Maria Aslam, Shahida Mohsin, Huma Amin, Shabbir Hussain, Nisar Ahmed, Ayesha Bhalli. Serum Transferrin Receptors in Children with Hypochromic Microcytic Anemia. Open Journal of Pathology, 2014, 4, **-** Published Online April 2014 in Sci Res. http://www.scirp.org/journal/ojpathology.
    7. Saira Bashir, Shahida Mohsin, Huma Amin, Muhammad Rehman, Shabbir Hussain, Tahir Saeed. Comparison of changes in platelet count, mean platelet, volume and swirling in stored platelet concentrates with and without platelet additive solution. Journal of Applied Hematology. 2014; 5(1) : 10-14.
      8. Year 2013
    8. Shahida Mohsin, Sameen Amjad, Huma amin, Tahir Saeed and Shabbir Hussain. Red cell Alloimmmunization in (2): repeatedly transfused cancer patients. Journal of Rawalpindi Medical college (JRMC) 2013; 17(2): 219-222.
    9. Syed Khizar Abbas Rizvi, Shahida Mohsin, Tahir Saeed, Saeed Ahmad, Shabbir Hussain Muhammad Ikram Ullah. Frequency of Clopidogrel Resistance in Patients of Ischemic Heart Disease; European Journal of Cardiovascular Medicine, 2013(2)3:176-180.
      10. Year 2012
    10. Mohsin Sh, Jaffar J, Hussain Sh, Suhail Sh, Ikram Ullah M, Amjad S. Detection of Factor VIII Inhibitors in Hemophilia A Patients. IJBC 2012; 4: 163-168.
    11. A Strategy for carrier detection in Pakistani haemophilia B families. M. Imran, M. T. Saeed, S. Mahmood. S.Mohsin, S.Sohail, A. Munir and H. Nazir, Hemophilia (2012), 1–2.
    12. Amin H, Mohsin S, Aslam M, Hussain S, Saeed T, Ullah Ml, Sami W. Coagulation factors and antithrombin levels in young and elderly subjects in Pakistani population. Blood Coagulation and Fibrinolysis 2012 Dec;23(8): 745-50.
    13. Shahida Mohsin, Huma Amin, Shabbir Hussain and Shahla Sohail. Hemophilia B: Clinical Manifestations and Complications. Biomedica, 8; 2012:52-56.
    14. Shahida Mohsin, Maria Aslam, Shabbir Hussain and Shahla Sohail. Clinical Manifestations and Complications of von Willibrand Disease..JRMC; 2012, 16(1):19-21.
    15. Shahida Mohsin, Dr. Khizer Abbass: Utility of Different Methods to Assess the Platelet Function Disorders. Hematology Updates Pakistan Society of Hematology (2012).
    16. Huma Amin, Shahida Mohsin: Hematological Applications of Flow cytometry: A Review, Hematology Updates Pakistan Society of Hematology (2012).
    17. Nadeem Ikram, Shahida Mohsin: Evidence Based Medicine: Hematology Updates Pakistan Society of Hematology (2012).
      18. Year 2011
    18. Shahida Mohsin, Amber Ilyas, Lubna Riaz Dar, Ghulam Rasool, Shabbir Hussain, M. Ikram Ullah. Levels of Anti-phospholipid Antibodies in Females with Recurrent Abortions. Ann. Pak. Inst. Med. Sci. 2011; 7(3): 156-159.
    19. Shahida Mohsin: Blood transfusion,complications and their prevention, Hematology Updates Pakistan Society of Hematology (2011).
      20. Year 2010
    20. Shahida Mohsin, Mahtab Aslam, Anees M, Shabbir Hussain, Tanvir Ahmed, Usman Qamar. Platelets Dysfunction in Patients of End Stage Renal Disease. BIOMEDICA; 26: 157-161(2010).
    21. Shahida Mohsin, Tahir Saeed, Shabbir Hussain, Saqib Mahmood, Shahla Sohail, Waqas Sami. Clinical Manifestations and Complications of Hemophilia A in Pakistan. Ann. Pak. Inst. Med. Sci. 2010; 6(3): 168-171.
    22. Ayesha Bhalli, Shahida Mohsin, Hemostatic abnormalities in chronic liver disease. Hematology Updates, Pakistan Society of Haematology: 143-148 (2010).
    23. Interpretation of Bone marrow trephine. Dr. Nadeem Ikram And Dr. Shahida Mohsin, Hematology Updates: (2010) .
      24. Year 2009
    24. Shahida Mohsin Clinical Applications of Apheresis. Hematology Updates, Pakistan Society of Hematology: 126-142 (2009).
      25. Year 2004
    25. Mohsin S, Anwar M, Rehman Z U, Waqar A, Ayyub M, Ali W. Value of D-Dimers assay in diagnoses of Pulmonary Embolism. J Pak Med Assoc; 54(7):348-52 (2004).
      26. Year 1999
    26. Shahida Mohsin, Wim Renmans, Serge Damiaens, Ivan Van Riet, Rik Schots, Marc De Waele. Enumeration of hematopoietic progenitor cells with flow cytometry: Comparison of different methods. Pak J Pathol; 10(2):16-25 (1999).

Faculty




Dr. Nazish Mazari
  • Head of Department
  • Assistant Professor
  • MBBS, FCPS(Haematology)
  • Ph: +9242-111 333 366 Ext: 356

Ghulam Mustafa
  • Lecturer
  • M.Phil MLS (Haematotechnology)
  • Ph: +9242-111 333 366 Ext: 356

Khansa Qamar
  • Lecturer
  • M.Phil (Haematology)
  • Ph: +9242-111 333 366 Ext: 356

Dr. Iram Aftab
  • Sr. Teching and Research Fellow [TRF]

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