UHS-Dept

Research Activities

HEC Won Grants by Haematology Department till 2021:

v Two HEC NRPU grants were won and completed by Haematology Department Students. Four M. Phil and one PHD students have completed their degrees under these projects. Their title detail is given as:

1. NRPU project No. 2093 with titled "Resistance to Antiplatelet Therapy in Patients of Ischemic Heart Disease."

2. NRPU project No. 2093 with titled "Genotype/Phenotype association in von Willebrand disease in Pakistani patients."

v Currently, in 2021, one PHEC-PIRCA grant has won by Haematology Department under the discipline of Hematogenetics and Cancer Biology. The detail title is given as:

3. PHEC-PIRCA Project titled "Investigating the Genetic Landscape of Acute Lymphoblastic Leukemia."

Haematology Department Research Publications by Faculty and Students till 2021

PhD Haematology Research Repository from 2015 to 2021

Haematology Department Research Repository

Degree

Student Name

Research Title

Supervisor

Status

PhD

Haematology

Dr. Asif Naveed

Genetic and Epigenetic alterations in type III von Willebrand disease

Prof. Dr. Shagufta Khaliq

In-Process

Dr. Shabnam Bashir

Analysis of quantitative trait loci (QTLs): HBG2, BCL11A, KLF1 and HBSILMYB genetic variants in patients with beta thalassemia

Prof. Dr. Saqib Mahmood

In-Process

Dr. Mizna Arif

Genomic profile of myeloproliferative neoplasms in patients presenting at tertiary care centre

Prof. Dr. Shagufta Khaliq

In-Process

Dr. Aisha Hameed

Clinico-haematological and molecular characterization of patients with chronic lymphocytic leukaemia

Prof. Dr. Shagufta Khaliq

In-Process


M. Phil Haematology Research Repository from 2009 to 2021

Haematology Department Research Repository

Degree

Student Name

Research Title

Supervisor

Status

M. Phil

Haematology

Dr. Tahir Saeed

Carrier detection of Haemophilia B by linkage analysis

Prof. Dr. Shahida Mohsin

Completed

Dr. Huma Amin

Evaluation of haemostatic changes with advancing age

Prof. Dr. Shahida Mohsin

Completed

Dr. Maria Aslam

Serum transferrin receptors in children with hypochromic microcytic anaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Ayesha Bhalli

Antithrombin III as a marker of fibrosis in chronic Hepatitis C

Prof. Dr. Shahida Mohsin

Completed

Dr. Khizer Abbas Naqvi

Resistance to antiplatelet therapy in patients of ischemic heart disease

Prof. Dr. Shahida Mohsin

Completed

Dr. Ammad Hassan Fida

Types and sub types of von Willibrand disease in local patients

Prof. Dr. Shahida Mohsin

Completed

Dr. Maida Masood

Nucleophosmin (NPM1) gene 4-bp dublication in patients with Acute Myeloid Leukaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Zille Rubab

Serum Hepcidin levels in patients of end stage renal disease on erythropoietin therapy

Prof. Dr. Shahida Mohsin

Completed

Dr. Azhar Sattar

Prevalence of Intron 1 inversion in patients of severe Haemophilia A

Prof. Dr. Shahida Mohsin

Completed

Dr. Muhammad Bilal

VKORC1 gene polymorphism (-1639G>A) and Warfarin resistance in patients on warfarin therapy

Prof. Dr. Shahida Mohsin

Completed

Dr. Jamshair Ali

Prevalence of Monoclonal Gammopathy of Undetermined Significance (MGUS) in Elderly

Prof. Dr. Shahida Mohsin

Completed

Dr. Munir Ahmed

Frequency of TEL AML1 fusion gene in patients of Acute Lymphoblastic Leukaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Iram Aftab

FANCC gene mutation (IVS4+4A>T, Del 322G, R548X) in local population

Prof. Dr. Shahida Mohsin

Completed

Dr. Saima Irum

Mutation of FANCA gene at exon 28 and 29 in patients of Fanconi Anaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Ayesha Hameed

Levels of Platelet Derived Microparticles and soluble P-selection in patients of myocardial infarction

Prof. Dr. Shahida Mohsin

Completed

Dr. Sadia Akbar

Frequency of BCR/ABL-1 fusion gene and deletion IKZF-1 in Acute Lymphoblastic Leukaemia patients

Prof. Dr. Shahida Mohsin

Completed

Dr. Nabila Akram

Role of CYP2C9 and PON-1 polymorphism in clopidogrel resistant patients of ischemic heart disease

Prof. Dr. Shahida Mohsin

Completed

Dr. Anum Amman

CYP2C9*2 polymorphism in patients of ischemic heart disease on clopidogrel therapy

Prof. Dr. Shahida Mohsin

Completed

Dr. Ujala

Mutation of FANCA gene (313G>T and 307+1G>T) in patients of Fanconi Anaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Mohammad Kashif

Intron 22 inversion in patients of severe haemophilia A.

Prof. Dr. Shahida Mohsin

In-Process

Dr. Ayesha Chaudhry

Comparison of Plasminogen Activator inhibitor (PAI-1), factor VII and Fibrinogen levels in obese and non-obese children

Prof. Dr. Shahida Mohsin

Completed

Dr. Shamila Tahir

Level of vWF and ADAMTS13 in patients of Myocardial Infarction

Prof. Dr. Shahida Mohsin

Completed

Dr. Maheen

Levels of Red Blood Cells derived microparticles in stored erythrocytes concentrate

Prof. Dr. Shahida Mohsin

Completed

Dr. Omer Naseem

Parvovirus B19 in Patients of Acute lymphoblastic leukemia with prolonged cytopenias

Prof. Dr. Shahida Mohsin

Completed

Dr. Moiza

Significance of Neuropilin-1(CD-304) expression in pediatric Acute Lymphoblastic Leukaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Yusra

Mutations at exons 11 and 17 of c-kit gene in patients with Acute Myeloid Leukemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Khurrum

Prevalence of L444P mutations of GBA gene in Pakistani patients of Gaucherís Disease

Prof. Dr. Shahida Mohsin

In-Process

Dr. Noureen

Diagnostic validity of total vitamin B12 and holotranscobalamin in patients of megaloblastic anaemia taking methylmelonyl CoA as gold standard

Prof. Dr. Shahida Mohsin

Completed

Dr. Sara Ejaz

Molecular characterization of Haemoglobin variants which co-elute with HbA2 on HPLC

Prof. Dr. Shahida Mohsin

Completed

Dr. Saira Gul

Flow Cytometric Analysis of ?IIb?3 Integrin Protein and its Activating Mutations in Exon 10 and 11 of ITGB3 Gene in Glanzmannís Thrombasthenia Patients.

Prof. Dr. Shahida Mohsin

Completed

Dr. Imran

Frequency of alpha thalassemia in pregnant women with microcytic hypochromic anaemias

Prof. Dr. Shahida Mohsin

In-Process

Dr. Afshan

Comparison of MTHFR C677T and A1298C Genetic Polymorphism in Chronic Myeloid Leukemia and normal healthy individuals

Dr. Nazish Mazari

In-Process

Dr. Aisha Ahmad

Comparison of Thrombomodulin, vWF & ADAMTS13 levels between preeclampsia and normal pregnancy.

Dr. Muhammad Asif Naveed

In-Process

Dr. Maryam Khalid

Tumor derived tissue factor positive micro particles in venous thromboembolism in cancer patients.

Dr. Nazish Mazari

In-Process

Dr. Shaista Shabbir

Association of FC gamma receptor 2B polymorphism with red blood cell alloimmunization in beta thalassemia major patients

Dr. Muhammad Asif Naveed

In-Process


M. Phil MLS Haematotechnology Research Repository from 2013 to 2021

Haematology Department Research Repository

Degree

Student Name

Research Title

Supervisor

Status

M. Phil MLS

Haematotechnology

Mr. Ghulam Mustafa

Single Nucleotide Polymorphism of P2RY12 and CYP3A5 Genes in Clopidogrel Resistant Ischemic Heart Disease Patients

Prof. Dr. Shahida Mohsin

Completed

Mr. Asgar Ali

Comparison of Activated Partial Thromboplastin time and Anti-Factor Xa assay in patients on Unfractionated Heparin Therapy

Prof. Dr. Shahida Mohsin

In-Process

Ms. Sumaira Khan

Stability of FV, FVII and FVIII in post thaw plasma units during refrigerated storage for 5 days

Prof. Dr. Shahida Mohsin

Completed

Mr. Ghulam Mustafa

Diagnostic validity of immunochromatographic strip technique for screening of alpha thalassemia taking PCR as a gold standard test

Prof. Dr. Shahida Mohsin

In-Process

Mr. M. Yaqoob

Frequency of inhibitors and homozygous gene (c.3622delT) in patients with type III von Willebrand disease

Prof. Dr. Shahida Mohsin

In-Process

Ms. Rida Fatima

Reticulocyte Haemoglobin Content as an Accurate Measure of Iron Status in the Evaluation of Iron Deficiency Anaemia

Prof. Dr. Shahida Mohsin

Completed

Ms. Samra Zaffar

Evaluation of Antierythropoietin Antibodies in Chronic Renal Failure patients undergoing Haemodialysis

Prof. Dr. Shahida Mohsin

Completed

Mr. Tahir Shah

Haematological Changes, Lactate Dehydrogenase and Red Blood Cells Antioxidant Enzyme Activity during Storage of Blood

Prof. Dr. Shahida Mohsin

Completed

Mr. M. Javed

Comparison of iron status, reticulocytes hemoglobin content and combined cell index between single time and frequent blood donors

Dr. Nazish Mazari

In-Process

Mr. M. Yousaf

Diagnostic validity of Elisa technique for the detection of Glanzmannís thrombasthenia

Dr. Nazish Mazari

In-Process

Ms. Sara Dilshad

Comparison of Mean platelet volume, Thrombopoietin levels and A5713G polymorphism in Acute Coronary Syndrome patients and controls

Prof. Dr. Shahida Mohsin

Completed

Mr. Roohullah

Frequency of MDR1 Gene Polymorphism (C3435T) in Acute Myeloid Leukemia Patients in tertiary care hospitals of Lahore

Dr. Nazish Mazari

Completed

M. Ramzan

Determination of CD25 on leukemic stem cells in

peripheral blood of chronic myeloid leukemia patients with and without tyrosine kinase inhibitors therapy

Mr. Ghulam Mustafa

In-Process

Ms. Javeria Sikandar

Erythrocyte alloimmunization and autoimmunization among multi transfused patients of chronic renal failure

Dr. Muhammad Asif Naveed

In-Process

Ms. Iqra Rabbani

Association of COX-I (rs1330344) gene polymorphism with aspirin resistance

Dr. Muhammad Asif Naveed

In-Process

Ahmad Ali

Comparative analysis of endothelial dysfunction and iron

deficiency markers in patients of polycythemia

Ms. Khansa Qamar

In-Process

PhD Haematology Research Repository from 2015 to 2021

Haematology Department Research Repository

Degree

Student Name

Research Title

Supervisor

Status

PhD

Haematology

Dr. Asif Naveed

Genetic and Epigenetic alterations in type III von Willebrand disease

Prof. Dr. Shagufta Khaliq

In-Process

Dr. Shabnam Bashir

Analysis of quantitative trait loci (QTLs): HBG2, BCL11A, KLF1 and HBSILMYB genetic variants in patients with beta thalassemia

Prof. Dr. Saqib Mahmood

In-Process

Dr. Mizna Arif

Genomic profile of myeloproliferative neoplasms in patients presenting at tertiary care centre

Prof. Dr. Shagufta Khaliq

In-Process

Dr. Aisha Hameed

Clinico-haematological and molecular characterization of patients with chronic lymphocytic leukaemia

Prof. Dr. Shagufta Khaliq

In-Process


M. Phil Haematology Research Repository from 2009 to 2021

Haematology Department Research Repository

Degree

Student Name

Research Title

Supervisor

Status

M. Phil

Haematology

Dr. Tahir Saeed

Carrier detection of Haemophilia B by linkage analysis

Prof. Dr. Shahida Mohsin

Completed

Dr. Huma Amin

Evaluation of haemostatic changes with advancing age

Prof. Dr. Shahida Mohsin

Completed

Dr. Maria Aslam

Serum transferrin receptors in children with hypochromic microcytic anaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Ayesha Bhalli

Antithrombin III as a marker of fibrosis in chronic Hepatitis C

Prof. Dr. Shahida Mohsin

Completed

Dr. Khizer Abbas Naqvi

Resistance to antiplatelet therapy in patients of ischemic heart disease

Prof. Dr. Shahida Mohsin

Completed

Dr. Ammad Hassan Fida

Types and sub types of von Willibrand disease in local patients

Prof. Dr. Shahida Mohsin

Completed

Dr. Maida Masood

Nucleophosmin (NPM1) gene 4-bp dublication in patients with Acute Myeloid Leukaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Zille Rubab

Serum Hepcidin levels in patients of end stage renal disease on erythropoietin therapy

Prof. Dr. Shahida Mohsin

Completed

Dr. Azhar Sattar

Prevalence of Intron 1 inversion in patients of severe Haemophilia A

Prof. Dr. Shahida Mohsin

Completed

Dr. Muhammad Bilal

VKORC1 gene polymorphism (-1639G>A) and Warfarin resistance in patients on warfarin therapy

Prof. Dr. Shahida Mohsin

Completed

Dr. Jamshair Ali

Prevalence of Monoclonal Gammopathy of Undetermined Significance (MGUS) in Elderly

Prof. Dr. Shahida Mohsin

Completed

Dr. Munir Ahmed

Frequency of TEL AML1 fusion gene in patients of Acute Lymphoblastic Leukaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Iram Aftab

FANCC gene mutation (IVS4+4A>T, Del 322G, R548X) in local population

Prof. Dr. Shahida Mohsin

Completed

Dr. Saima Irum

Mutation of FANCA gene at exon 28 and 29 in patients of Fanconi Anaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Ayesha Hameed

Levels of Platelet Derived Microparticles and soluble P-selection in patients of myocardial infarction

Prof. Dr. Shahida Mohsin

Completed

Dr. Sadia Akbar

Frequency of BCR/ABL-1 fusion gene and deletion IKZF-1 in Acute Lymphoblastic Leukaemia patients

Prof. Dr. Shahida Mohsin

Completed

Dr. Nabila Akram

Role of CYP2C9 and PON-1 polymorphism in clopidogrel resistant patients of ischemic heart disease

Prof. Dr. Shahida Mohsin

Completed

Dr. Anum Amman

CYP2C9*2 polymorphism in patients of ischemic heart disease on clopidogrel therapy

Prof. Dr. Shahida Mohsin

Completed

Dr. Ujala

Mutation of FANCA gene (313G>T and 307+1G>T) in patients of Fanconi Anaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Mohammad Kashif

Intron 22 inversion in patients of severe haemophilia A.

Prof. Dr. Shahida Mohsin

In-Process

Dr. Ayesha Chaudhry

Comparison of Plasminogen Activator inhibitor (PAI-1), factor VII and Fibrinogen levels in obese and non-obese children

Prof. Dr. Shahida Mohsin

Completed

Dr. Shamila Tahir

Level of vWF and ADAMTS13 in patients of Myocardial Infarction

Prof. Dr. Shahida Mohsin

Completed

Dr. Maheen

Levels of Red Blood Cells derived microparticles in stored erythrocytes concentrate

Prof. Dr. Shahida Mohsin

Completed

Dr. Omer Naseem

Parvovirus B19 in Patients of Acute lymphoblastic leukemia with prolonged cytopenias

Prof. Dr. Shahida Mohsin

Completed

Dr. Moiza

Significance of Neuropilin-1(CD-304) expression in pediatric Acute Lymphoblastic Leukaemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Yusra

Mutations at exons 11 and 17 of c-kit gene in patients with Acute Myeloid Leukemia

Prof. Dr. Shahida Mohsin

Completed

Dr. Khurrum

Prevalence of L444P mutations of GBA gene in Pakistani patients of Gaucherís Disease

Prof. Dr. Shahida Mohsin

In-Process

Dr. Noureen

Diagnostic validity of total vitamin B12 and holotranscobalamin in patients of megaloblastic anaemia taking methylmelonyl CoA as gold standard

Prof. Dr. Shahida Mohsin

Completed

Dr. Sara Ejaz

Molecular characterization of Haemoglobin variants which co-elute with HbA2 on HPLC

Prof. Dr. Shahida Mohsin

Completed

Dr. Saira Gul

Flow Cytometric Analysis of ?IIb?3 Integrin Protein and its Activating Mutations in Exon 10 and 11 of ITGB3 Gene in Glanzmannís Thrombasthenia Patients.

Prof. Dr. Shahida Mohsin

Completed

Dr. Imran

Frequency of alpha thalassemia in pregnant women with microcytic hypochromic anaemias

Prof. Dr. Shahida Mohsin

In-Process

Dr. Afshan

Comparison of MTHFR C677T and A1298C Genetic Polymorphism in Chronic Myeloid Leukemia and normal healthy individuals

Dr. Nazish Mazari

In-Process

Dr. Aisha Ahmad

Comparison of Thrombomodulin, vWF & ADAMTS13 levels between preeclampsia and normal pregnancy.

Dr. Muhammad Asif Naveed

In-Process

Dr. Maryam Khalid

Tumor derived tissue factor positive micro particles in venous thromboembolism in cancer patients.

Dr. Nazish Mazari

In-Process

Dr. Shaista Shabbir

Association of FC gamma receptor 2B polymorphism with red blood cell alloimmunization in beta thalassemia major patients

Dr. Muhammad Asif Naveed

In-Process


M. Phil MLS Haematotechnology Research Repository from 2013 to 2021

Haematology Department Research Repository

Degree

Student Name

Research Title

Supervisor

Status

M. Phil MLS

Haematotechnology

Mr. Ghulam Mustafa

Single Nucleotide Polymorphism of P2RY12 and CYP3A5 Genes in Clopidogrel Resistant Ischemic Heart Disease Patients

Prof. Dr. Shahida Mohsin

Completed

Mr. Asgar Ali

Comparison of Activated Partial Thromboplastin time and Anti-Factor Xa assay in patients on Unfractionated Heparin Therapy

Prof. Dr. Shahida Mohsin

In-Process

Ms. Sumaira Khan

Stability of FV, FVII and FVIII in post thaw plasma units during refrigerated storage for 5 days

Prof. Dr. Shahida Mohsin

Completed

Mr. Ghulam Mustafa

Diagnostic validity of immunochromatographic strip technique for screening of alpha thalassemia taking PCR as a gold standard test

Prof. Dr. Shahida Mohsin

In-Process

Mr. M. Yaqoob

Frequency of inhibitors and homozygous gene (c.3622delT) in patients with type III von Willebrand disease

Prof. Dr. Shahida Mohsin

In-Process

Ms. Rida Fatima

Reticulocyte Haemoglobin Content as an Accurate Measure of Iron Status in the Evaluation of Iron Deficiency Anaemia

Prof. Dr. Shahida Mohsin

Completed

Ms. Samra Zaffar

Evaluation of Antierythropoietin Antibodies in Chronic Renal Failure patients undergoing Haemodialysis

Prof. Dr. Shahida Mohsin

Completed

Mr. Tahir Shah

Haematological Changes, Lactate Dehydrogenase and Red Blood Cells Antioxidant Enzyme Activity during Storage of Blood

Prof. Dr. Shahida Mohsin

Completed

Mr. M. Javed

Comparison of iron status, reticulocytes hemoglobin content and combined cell index between single time and frequent blood donors

Dr. Nazish Mazari

In-Process

Mr. M. Yousaf

Diagnostic validity of Elisa technique for the detection of Glanzmannís thrombasthenia

Dr. Nazish Mazari

In-Process

Ms. Sara Dilshad

Comparison of Mean platelet volume, Thrombopoietin levels and A5713G polymorphism in Acute Coronary Syndrome patients and controls

Prof. Dr. Shahida Mohsin

Completed

Mr. Roohullah

Frequency of MDR1 Gene Polymorphism (C3435T) in Acute Myeloid Leukemia Patients in tertiary care hospitals of Lahore

Dr. Nazish Mazari

Completed

M. Ramzan

Determination of CD25 on leukemic stem cells in

peripheral blood of chronic myeloid leukemia patients with and without tyrosine kinase inhibitors therapy

Mr. Ghulam Mustafa

In-Process

Ms. Javeria Sikandar

Erythrocyte alloimmunization and autoimmunization among multi transfused patients of chronic renal failure

Dr. Muhammad Asif Naveed

In-Process

Ms. Iqra Rabbani

Association of COX-I (rs1330344) gene polymorphism with aspirin resistance

Dr. Muhammad Asif Naveed

In-Process

Ahmad Ali

Comparative analysis of endothelial dysfunction and iron

deficiency markers in patients of polycythemia

Ms. Khansa Qamar

In-Process