Research Publications of AHS

Sr. No




Rauff B, Amar A, Chudhary SA, Mahmood S, Tayyab GUN, Hanif R Interferon-? rs12979860 genotype association with liver fibrosis in chronic hepatitis C (CHC) patients in the Pakistani population. Arch Virol. 2021 Feb 2. doi: 10.1007/s00705-020-04901-2. Online ahead of print.


Pervaiz A, Zepp M, Georges R, Bergmann F, Mahmood S, Faiza S, Berger MR, Adwan H. Antineoplastic effects of targeting CCR5 and its therapeutic potential for colorectal cancer liver metastasis. J Cancer Res Clin Oncol. 2021 Jan;147(1):73-91.


Bashir S, Mahmood S, Mohsin S, Tabassum I, Ghafoor M, Sajjad O. Modulatory effect of single nucleotide polymorphism in Xmn1, BCL11A and HBS1L-MYB loci on foetal haemoglobin levels in ?-thalassemia major and Intermedia patients. J Pak Med Assoc. 2021 May;71(5):1394-1398. doi: 10.47391/JPMA.1351. PMID: 34091621.


Anjum, R., Mehmood, S., Nagi, A.H., Shahzad, M.A. and Chuadhry, S., Determination of single nucleotide polymorphism (rs566926) of Wnt5a in non-syndromic cleft lip and palate in a Pakistani population. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2021. 132(1), p.e7.



Shahid M, Idrees M, Butt AM, Raza SM, Amin I, Rasul A, Afzal S. Blood-based gene expression profile of oxidative stress and antioxidant genes for identifying surrogate markers of liver tissue injury in chronic hepatitis C patients. Arch Virol. 2020. Apr;165(4):809-822


Sajjad O, Shahzad, M.A. and Mahmood S. RT-PCR for COVID-19: diagnosis made easy. Biomedica. 2020; 36 (COVID19- S2): 115-20.


Albegali, A.A., Shahzad, M., Mahmood, S., Ikram, U., Amar, A., Sajjad, O. Genetic polymorphism of eNOS (G894T) gene in insulin resistance in type 2 diabetes patients of Pakistani population. Int J Diabetes Dev Ctries 2020. 40, 203�208. https://doi.org/10.1007/s13410-019-00775-6


Ahmad, I., Nygren, E., Khalid, F., Myint, S.L. and Uhlin, B.E., A Cyclic-di-GMP signalling network regulates biofilm formation and surface associated motility of Acinetobacter baumannii 17978. Scientific reports. 2020. 10(1), pp.1-11.


Khalid, F., Saleem, S. and Ahmad, I., High prevalence of carbapenem-resistant Acinetobacter baumannii associated respiratory tract infections in Pakistani hospitals. JPMA. The Journal of the Pakistan Medical Association, 2020. 70(9), pp.1630-1632.


Mannan, T., Rafique, M.W., Bhatti, M.H., Matin, A. and Ahmad, I. Type 1 Fimbriae and Motility Play a Pivotal Role During Interactions of Salmonella typhimurium with Acanthamoeba castellanii (T4 Genotype). Current microbiology. 2020. pp.1-10.


Karah, N., Khalid, F., Wai, S.N., Uhlin, B.E. and Ahmad, I. Molecular epidemiology and antimicrobial resistance features of Acinetobacter baumannii clinical isolates from Pakistan. Annals of clinical microbiology and antimicrobials. 2020. 19(1), pp.1-13.


Fatima W, Riaz S, Shahzad M.A., Naz Z, Mahmood S, Hasnain S Chromosomal region 1q24.1 is associated with increased risk of schizophrenia in Pakistani population. Gene. 2020 Apr 15;734:144390. doi: 10.1016/j.gene.2020.144390. Epub 2020 Jan 24.



Albegali AA, Shahzad M, Mahmood S, Ullah MI. Genetic association of insulin receptor substrate-1 (IRS-1, rs1801278) gene with insulin resistant of type 2 diabetes mellitus in a Pakistani population. Mol Biol Rep. 2019 Dec;46(6):6065-6070. doi: 10.1007/s11033- 019-05041-w. Epub 2019 Aug 24.


Shakil M, Harlalka GV, Ali S, Lin S, D'Atri I, Hussain S, Nasir A, Shahzad MA, Ullah MI, Self JE, Baple EL, Crosby AH, Mahmood S. Tyrosinase (TYR) gene sequencing and literature review reveals recurrent mutations and multiple population founder gene mutations as causative of oculocutaneous albinism (OCA) in Pakistani families. Eye (Lond). 2019 Apr 17. doi: 10.1038/s41433-019-0436-9. [Epub ahead of print]


von Schnurbein J, Manzoor J, Brandt S, Denzer F, Kohlsdorf K, Fischer-Posovszky P, Wei�enberger M, Frank-Podlech S, Mahmood S, Wabitsch M. Leptin is not Essential for Obesity-Associated Hypertension Obes Facts. 2019;12(4):460-475. doi: 10.1159/000501319. Epub 2019 Jul 29.


Rashid M, Shahzad M, Mahmood S, Khan K Variability in the therapeutic response of Metformin treatment in patients with type 2 diabetes mellitus. Pak J Med Sci. 2019 Jan-Feb;35(1):71-76. doi: 10.12669/pjms.35.1.100.PMID: 30881399


Ahmad, I., Karah, N., Nadeem, A., Wai, S.N. and Uhlin, B.E. Analysis of colony phase variation switch in Acinetobacter baumannii clinical isolates. PLoS One. 2019. 14(1), p.e0210082.


Shahid S, Ghaznavi S, Rasheed S, Raza SM, Ullah MI, Shakil M. Lack of Genetic Association between SNP Rs7903146 (Ivs3c>T) of Transcription Factor 7 Like 2 (Tcf7l2) Gene in Type 2 Diabetes Mellitus in Pakistani Population. Pak J Med Health Sci. 2019 July-Sep 13(3): 819-822.


Shahid M, Idrees M, Butt AM, Raza SM, Amin I, Rasul A, Afzal S, Zahid S, Nawaz R. Short article: Hepatitis C and G virus coinfection in Punjab, Pakistan: incidence and its correlation analysis with clinical data. Eur J Gastroenterol Hepatol. 2019 Mar;31(3):389-392.


Albegali, A.A., Shahzad, M., Ullah, M.I., Mahmood, S. and Rashid, M. Association of genetic polymorphism of PC?1 gene (rs1044498 Lys121Gln) with insulin?resistant type 2 diabetes mellitus in Punjabi Population of Pakistan. Molecular genetics & genomic medicine. 2019. 7(8), p.e775.


Zahra, A., Naveed, M., Ahmad, I., Saleem, M.A. and Zeshan, B. The syringes catastrophe of the HIV outbreak in Faisalabad, Punjab, Pakistan. Future Medicine. 2019. 571-572.



Pervaiz, A., Zepp, M., Mahmood, S., Ali, D.M., Berger, M.R. and Adwan, H. CCR5 blockage by maraviroc: a potential therapeutic option for metastatic breast cancer. Cellular Oncology, 2019. 42(1), pp.93-106.


Adwan, H., Elharouni, D., Habashy, D., Banna, N., Georges, R., Pervaiz, A. and Berger, M.R. Early Metastasis in Colorectal Cancer Poses an Option for New Diagnostic and Treatment Strategies. In Cancer Metastasis. IntechOpen. 2018.


Frank-Podlech S, von Schnurbein J, Veit R, Heni M, Machann J, Heinze JM, Kullmann S, Manzoor J, Mahmood S, H�ring HU, Preissl H, Wabitsch M, Fritsche A. Leptin Replacement Reestablishes Brain Insulin Action in the Hypothalamus in Congenital Leptin Deficiency. Diabetes Care. 2018 Apr;41(4):907-910. doi: 10.2337/dc17-1867. Epub 2018 Jan 24.


Gill, M.A., Rafique, M.W., Manan, T., Slaeem, S., R�mling, U., Matin, A. and Ahmad, I. The cellulose synthase BcsA plays a role in interactions of Salmonella typhimurium with Acanthamoeba castellanii genotype T4. Parasitology research, 2018. 117(7), pp.2283-2289.


Ahmad A, Mushtaq F, Saleem S and Ahmad I, Analysis of Multi Drug Resistant Mycobacterium tuberculosis Clinical Isolates for Susceptibility to Linezolid and Verapamil using MGIT 960. Saudi J. Med. Pharm. Sci. 2018. Vol-4, Iss-10: 1205-1213.


Zahra S. p.Y556C is recurrent mutation in Pendred Syndrome causing Gene SLC26A4 in Punjabi Population. Pakistan J. Zool. 2018. Vol. 50, Iss. 3, pp 1113-1118.


Khaliq S, Raza SM. Current Status of Direct Acting Antiviral Agents against Hepatitis C Virus Infection in Pakistan. Medicina (Kaunas). 2018 Nov 5;54(5):80.


Naeemi H, Aslam R, Raza SM, Shahzad MA, Naz S, Manzoor S, Khaliq S. Distribution of IL28B and IL10 polymorphisms as genetic predictors of treatment response in Pakistani HCV genotype 3 patients. Arch Virol. 2018 Apr;163(4):997-1008.


Hussain R, Khaliq S, Raza SM, Khaliq S, Lone KP. Association of TP53 codon 72 polymorphism in women suffering from endometriosis from Lahore, Pakistan. J Pak Med Assoc. 2018 Feb;68(2):224-230.


Rashid, M., Shahzad, M., Mahmood, S. and Khan, K. Variability in the therapeutic response of Metformin treatment in patients with type 2 diabetes mellitus. Pakistan journal of medical sciences. 2019. 35(1), p.71.


Pervaiz, A., Akhtar, M.S., Mahmood, S., Sajjad, O., Khaliq, S. and Berger, M.R.Molecular basis of cell cycle arrest induced by erufosine in metastatic breast cancer cells.Cancer Research. 2018. 10.1158/1538-7445.



Adwan, H., Georges, R., Pervaiz, A. and Berger, M.R. Investigation of metastasis-related genes: A rat model mimicking liver metastasis of colorectal carcinoma. Frontiers in oncology, 2017. 7, p.152.


Ullah MI, Ahmad A, Zarkovic M, Shah SS, Nasir A, Mahmood S, Ahmad W, Hubner CA, Hassan MJ. Novel duplication mutation of the DYSF gene in a Pakistani family with Miyoshi Myopathy. Saudi Med J. 2017 Dec;38(12):1190-1195.


Shahzad MA, Khaliq S, Amar A, Mahmood S Metachromatic Leukodystrophy (MLD): a Pakistani Family with Novel ARSA Gene Mutation. J Mol Neurosci. 2017 Aug 10. doi: 10.1007/s12031-017-0959-0.


Sattar A, Hussain S, Ullah MI, Mahmood S, Mohsin S. Screening of Intron 1 Inversion of Factor VIII gene in 130 patients with severe Haemophilia A from Pakistani cohort. Turk J Haematol. 2017 Mar 15.


El Mouali, Y., Kim, H., Ahmad, I., Brauner, A., Liu, Y., Skurnik, M., Galperin, M.Y. and R�mling, U. Stand-alone EAL domain proteins form a distinct subclass of EAL proteins involved in regulation of cell motility and biofilm formation in enterobacteria. Journal of bacteriology. 2017. 199(18), pp.e00179-17.


Detailed analysis of c-di-GMP mediated regulation of csgD expression in Salmonella typhimurium. Ahmad I, Cimdins A, Beske T, R�mling U. BMC Microbiology. 2017 Feb 2;17(1):27.


Cimdins, A., L�thje, P., Li, F., Ahmad, I., Brauner, A. and R�mling, U. Draft genome sequences of semiconstitutive red, dry, and rough biofilm-forming commensal and uropathogenic Escherichia coli isolates. Genome announcements. 2017. 5(4), pp.e01249-16.


Faridi R, Rehman AU, Morell RJ, Friedman PL, Demain L, Zahra S et al. Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome. Clin Genet. 2017 Feb; 91(2):328-332.


Bhatti FU, Mehmood A, Latief N, Zahra S, Cho H, Khan NS, Riazuddin S. 2017. Vitamin E protects rat mesenchymal stem cells against hydrogen peroxide-induced oxidative stress in vitro and improves their therapeutic potential in surgically-induced rat model of osteoarthritis.Osteoarthritis and Cartilage. 25: 321-331.



Shakil M, Ullah MI, Hussain S, Firasat S, Mahmood S, Kaul H. Homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene. Int J Ophthalmol. 2016 May 18;9(5):794-6.


Aziz F, Fatima W, Mahmood S, Khokher S. Screening for Del 185 AG and 4627C>A BRCA1 Mutations in Breast Cancer Patients from Lahore, Pakistan. Asian Pac J Cancer Prev. 2016;17(4):1725-7.


Khokher S, Qureshi MU, Mahmood S, Sadiq S. Determinants of Advanced Stage at Initial Diagnosis of Breast Cancer in Pakistan: Adverse Tumor Biology vs Delay in Diagnosis. Asian Pac J Cancer Prev. 2016;17(2):759-65.


Ahmad I, Rouf SF, Sun L, Cimdins A, Shafeeq S, Le Guyon S, Schottkowski M, Rhen M, R�mling U. BcsZ inhibits biofilm phenotypes and promotes virulence by blocking cellulose production in Salmonella entericaserovar Typhimurium. Microb Cell Fact. 2016, 15(1):177.


Aslam R, Raza SM, Naeemi H, Mubarak B, Afzal N, Khaliq S. SOCS3 mRNA expression and polymorphisms as pretreatment predictor of response to HCV genotype 3a IFN-based treatment. Springerplus. 2016 Oct 21;5(1):1826.


Abstract accepted and published on the topic of �Chromosomal aberrations in Turner Syndrome phenotype� in �2nd Multi-Disciplinary Student Research Conference� held on 21st -22nd December, 2016 in the University of Wah, Wah Cantt, Pakistan.



Shahid A, Rana S, Mahmood S, Saeed S. Role of leptin G-2548A polymorphism in age- and gender-specific development of obesity. J Biosci. 2015 Sep;40(3):521-30.


Khokher S, Qureshi MU, Fatima W, Mahmood S, Saleem A. Impact of a Breast Health Awareness Activity on the Knowledge Level of the Participants and its Association with Socio- Demographic Features. Asian Pac J Cancer Prev. 2015;16(14):5817-22.


Mohsin SN, Mahmood S, Amar A, Ghafoor F, Raza SM, Saleem M. Association of Fc?RIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan. Am J Trop Med Hyg. 2015 Oct;93(4):691-6.


Imdad, S., Ahmed, T., Yaldram, K., Raza, SM., Awareness and Attitude about Nanotechnology: Pakistan scenario. J Nano Educ. 2015; 7 44-51.


Asif M., Raza SM., Ahmed A. Research Trend, Career Preferences and its Effective Factors among Undergraduate Medical Students in Jinnah Sind Medical University, Pakistan. FMEJ 2015; 5(3) 3-7.



Rana S, Shahid A, Ullah H, Mahmood S. Lack of Association of the NPAS2 Gene Ala394Thr Polymorphism (rs2305160:G>A) with Risk of Chronic Lymphocytic Leukemia. Asian Pac J Cancer Prev. 2014;15(17):7169-74.


Rana S, Munawar M, Shahid A, Malik M, Ullah H, Fatima W, Mohsin S, Mahmood S. Deregulated expression of circadian clock and clock-controlled cell cycle genes in chronic lymphocytic leukemia. Mol Biol Rep. 2014 Jan;41(1):95-103.


Simm R, Ahmad I, Rhen M, Le Guyon S, R�mling U. Regulation of biofilm formation in Salmonella entericaserovar Typhimurium. Future Microbiol. 2014;9(11):1261-82.


Fang, X., Ahmad, I., Blanka, A., Schottkowski, M., Cimdins, A., Galperin, M.Y., R�mling, U. and Gomelsky, M. GIL, a new c?di?GMP?binding protein domain involved in regulation of cellulose synthesis in enterobacteria. Molecular microbiology. 2014. 93(3), pp.439-452.


Shahid M, Idrees M, Nasir B, Raja AJ, Raza SM, Amin I, Rasul A, Tayyab GU. Correlation of biochemical markers and HCV RNA titers with fibrosis stages and grades in chronic HCV-3a patients. Eur J Gastroenterol Hepatol. 2014 Jul;26(7):788-94.



Koehler K, Malik M, Mahmood S, Gie�elmann S, Beetz C, Hennings JC, Huebner AK, et.,al. Mutations in GMPPA Cause a Glycosylation Disorder Characterized by Intellectual Disability and Autonomic Dysfunction. Am J Hum Genet. 2013 Oct 3;93(4):727-734.


Shahid A, Rana S, Saeed S, Imran M, Afzal N, Mahmood S. Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females. Biomed Res Int. 2013. Epub 2013 Sep 2.


Ejaz H, Ikram-ul-Haq, Mahmood S, Zafar A, Javed MM. Detection of extended-spectrum ?-lactamases in Klebsiella pneumoniae: Comparison of phenotypic characterization methods. Pak J Med Sci 2013;29(3):768-772.


Khokher S, Qureshi MU, Mahmood S, Nagi AH. Association of immunohistochemically defined molecular subtypes with clinical response to resurgical chemotherapy in patients with advanced breast cancer. Asian Pac J Cancer Prev. 2013;14(5):3223-8.


Bijarnia S, Kohli S, Puri RD, Jacob RJ, Saxena R, Jalan A, Sistermans EA, Mahmood S, Verma IC. Molecular Characterisation and Prenatal Diagnosis of Asparto-acylase Deficiency (Canavan disease)-Report of Two Novel and Two Known Mutations from the Indian Subcontinent. Indian J Pediatr. 2013 Jan;80(1):26-31.



Mahmood U, Imran M, Naik SI, Cheema HA, Saeed A, Arshad M, Mahmood S. Detection of common mutations in the GALT gene through ARMS. Gene. 2012 Nov 10;509 (2):291-4.


Imran M, Saeed MT, Mahmood S, Mohsin S, Sohail S, Munir A, Nazir H. A strategy for carrier detection in Pakistani haemophilia B families. Haemophilia. 2012 Jul;18(4):e348-9.


Shahid A, Saeed S, Rana S, Mahmood S. Family history of diabetes and parental consanguinity: important risk for impaired fasting glucose in south east Asians. West Indian Med J. 2012 Jun;61(3):219-23.


Imran M, Mahmood S, Babar ME, Hussain R, Yousaf MZ, Abid NB, Lone KP PRNP gene variation in Pakistani cattle and buffaloes. Gene. 2012 Aug 15;505(1):180-5.


Bugvi SM, Imran M, Mahmood S, Hafeez R, Fatima W, Sohail S. Screening of intron 1 inversion and three intragenic factor VIII gene polymorphisms in Pakistani hemophilia A families. Blood Coagul Fibrinolysis. 2012 Mar;23(2):132-7.


Imran M, Mahmood S, Hussain R, Abid NB, Lone KP Frequency distribution of PRNP polymorphisms in the Pakistani population. Gene. 2012 Jan 15;492(1):186-94.


Idrees M, Hussain W, Rehman H, Tayyab N, Afzal S, Fatima Z, Akram M, Raza SM, Ali L, Hussain A, Amin I, Shahid M, Khubaib B, Saleem S, Nasir B, Tariq A, Wasim M, Waqar M. Dengue Virus Serotype 2 (DEN-2): The Causative Agent of 2011-Dengue Epidemic in Pakistan. Am J Biomed Sci. 2012; 4(4) 307-315.


Samreen, B., Khaliq, S., Ashfaq, U. A., Khan, M., Afzal, N., Shahzad, M. A., Riaz, S. & Jahan, S. Hepatitis C virus entry: Role of host and viral factors. Infect Genet Evol 2012, 12, 1699-1709. (Impact Factor: 2.611)



Mahmood S, Beetz C, Tahir MM, Imran M, Mumtaz R, Bassmann I, Jahic A, Malik M, N�rnberg G, Ali Hassan SA, Rana S, N�rnberg P, Huebner CA. First HPSE2 missense mutation in Urofacial Syndrome. Clin Genet. 2011, Feb 17. doi: 10.1111/j.1399-0004.2011.01649.x.


Imran M, Mahmood S. An overview of human prion diseases. Virol J. 2011 Dec 24;8(1):559.


Khokher S, Qureshi W, Mahmood S, Saleem A, Mahmud S. Knowledge, Attitude and Preventive Practices of Women for Breast cancer in the Educational Institutions of Lahore, Pakistan. Asian Pac J Cancer Prev. 2011;12(9):2419-24.


Imran M, Mahmood S. An overview of animal prion diseases. Virol J. 2011 Nov 1;8 (1):493.


Kausar R, Hassan MJ, Khan B, Basit S, Mahmood S, Mir A, Ahmad W, Ansar M Mutations in WDR62 gene in Pakistani families with autosomal recessive primary microcephaly BMC Neurol. 2011 Oct 1;11(1):119


Fatima W, Shahid A, Imran M, Manzoor J, Hasnain S, Rana S, Mahmood S Leptin deficiency and leptin gene mutations in obese children from Pakistan Int J Pediatr Obes. 2011 Oct;6(5-6):419-27.


Khokhar S, Mahmood S, Qureshi MU, Khan SA, Chaudhry NA �Initial Clinical Response� to noeadjuvant chemotherapy: An In-vivo chemosensitivity test for efficacy in patients with advanced breast cancer Asian Pac J Cancer Rev. 2011, 12(4):939-46


Mahmood S, Ahmad W, Hassan MJ Autosomal Recessive Primary Microcephaly (MCPH): Clinical manifestations, genetic heterogeneity and mutation continuum. Orphanet journal of rare diseases. 2011. 6(1), pp.1-15.