UHS-Dept

Research Activities

Faculty Research Interests:

Dr Saqib Mahmood

  • Medical Genetics
  • Neurodegenerative Diseases
  • Neuromuscular Diseases
  • Dysmorphology
  • Complex Genetic Disorders

Dr Irfan Ahmed

  • Molecular Infectious Medicine
  • Host Pathogen Interaction Studies
  • Molecular Basis of Antimicrobial Drug Resistance

Dr Asim Pervaiz

  • Molecular Medicine
  • Cancer Genetics
  • Functional Genomics of Cancer

Dr Sana Zahra

  • Genetics of Hearing Impairment
  • Genetics of Craniofacial Anomalies

Mr Syed Mohsin Raza

  • Molecular Biology
  • Molecular Virology
  • Bioinformatics &Computational Biology

Ms Osheen Sajjad

  • Molecular Oncology
  • Hemoglobinopathies
  • Congenital Bleeding Disorders
  • Cytogenetics

Mr Aiman Shahzad

  • Medical Genetics
  • Neurodegenerative Disorders
  • Functional Genomics

Grants Won:

1. Grant from Higher Education Commission worth Rs.1,720,740/- for "Inflammation in Stroke: Curriculum of Cytokines (TNF-Alpha & IL-10) and Homocystine in Clinical Stroke"

2. Grant from Higher Education Commission worth Rs.29,67,550/- for "Molecular Genetic Study in Pakistani Families with Schizophrenia

3. Grant from Pakistan Science Foundation worth Rs. 1,076,420/- for the project title "Molecular Genetic Studies in Pakistani Families with Autosomal Recessive Microcephaly"

4. Grant from Pakistan Science Foundation worth. Rs 592,000/- for the project title. "Molecular Genetics and Biochemical Studies in Familial Oculocutaneous Albinism (OCA)"

5. Grant from Punjab Higher Education Commission worth Rs.8,500,000/- for "Investigating the Genetic Landscape of Acute Lymphoblastic Leukemia"

6. Characterization of locally isolated strains of Acinetobacter baumannii for drug resistance and biofilm formation.

Start-up Research Grant Program (SRGP) by Higher Education Commission (HEC) of Pakistan Worth: 0.5million PKR (2016-2017)

7. Anticancer effects of Erufosine in breast and colorectal cancer cells

Start-up Research Grant Program (SRGP) by Higher Education Commission (HEC) of Pakistan Worth: 0.45million PKR (2016-2017)

8. Analysis of Acinetobacter baumannii for virulence features, drug resistance and alternative treatment options

National Research Program for Universities (NRPU) by Higher Education Commission (HEC) of Pakistan Worth: 8.23million PKR (2017-2020)

9. pre-clinical evaluation of a candidate drug for metastatic breast cancer

National Research Program for Universities (NRPU) by Higher Education Commission (HEC) of Pakistan Worth: 4.9million PKR (2018-2021)

10. Network on bridging gap in adaptive drug resistance and fitness properties of Gram-negative bacteria VR2020 Research Grant by Swedish Research Council, Sweden. Worth: 6 Million SEK (2020-21)

Research Thesis of Students

Sr. No.

Student Names

Title of Thesis

1.

Ayesha Rahim

KLF1 Exon 2 variations and their association with HbF and HbA2 levels in beta thalassemia

2.

M. Ali

Erufosine mediated effects on transcriptomic profile of tumor suppressors and oncogenes in breast cancer cells

3.

Ubaid Ullah

Effects of erufosine on cell cycle related genes in liver cancer cell

4.

Nazakat Shafiq

Riproximin mediated cytotoxic effects and expressional modifications in cell cycle related genes in liver cancer cells

5.

Kinza Kanwal

Cytotoxic effects of alkyl-phospholipids (Erufosine and Perifosine) in combination with cell cycle check point inhibitors (ATM and ATR) in breast cancer cells

6.

Saba Saeed

Effects of a ribosomal inactivating plant protein (riproximin) on transcriptomic profile of tumor suppressor and oncogenes in breast cancer cells

7.

Adeela Batool

Riproximin mediated cytostatic effects and expressional modifications in cell cycle related genes in lung cancer cells

8.

Maryum Nasim

Effects of erufosine on cell cycle and its related genes in lung cancer cells

9.

Kiran Riaz

Effects of riproximin on expressional profiling of apoptosis related genes in breast cancer

10.

Asma Khan

Riproximin mediated effects on transcriptomic profile of PI3K/Akt/mTOR pathway in breast cancer cells

11.

Iqra Shaukat

Toxic effects of synthetic alkyl-phospholipids (Erfufosine) in combination with chemotherapeutic agents (5-FU and Oxaliplatin) against colorectal cancer cells

12.

Talha Saleem

Effects of riproximin on expressional profiling of anticancer genes in breast cancer cells

13.

Sobia Javeed

Effects of CCR5 and CXCR4 blockage on cell survival and expression levels of apoptosis related genes (FAS, FASL) in hepatocellular carcinoma cells

14.

M. Masood

Effects of synthetic alkyl-phospholipids on proliferation and cell cycle relevant genes (CCNA1, CCNA2, CCND1) of hepatocellular carcinoma cells

15.

M. Shoaib

Molecular basis of cell cycle arrest by erufosine in breast and colorectal cancer cells

16.

Syeda Shafia

Riproximin mediated effects on cell cycle relevant genes in breast & colorectal cancer cells

17.

Syeda Faiza

Circulating chemokine levels in colorectal cancer patients and healthy population

18.

Abdul Salam

Levels of Serum Uric Acid in Young Adults

19.

Muhammad Arshad Nadeem

Mutational Analysis of Thiopurine S-Methyltransferase (TPMT) gene in Acute Lymphoblastic Leukemia Patients

20.

Sana Tariq

Gene Expression Analysis of Adiponectin Receptor -2 and Insulin Receptor in Chronic HCV Patients with Type 2 Diabetes Mellitus

21.

Khadija Tahir

Molecular Detection of TEM and CTX-M Genes in Extended Spectrum-?-Lactamases (ESBL) Producing Gram-Negative Rods

22.

Sidra Javed

Anti Mullerian Hormone as a marker of ovarian dysfunction and insulin resistance in PCOS patients.

23.

Sana Tamoori

Prevalence of Antithyroid antibody in Patients of Hepatitis C Infection of Genotype 3a

24.

Saeeda Riaz

Gene Expression Analysis of Tumor Necrosis Factor Alpha (TNF-alpha) and Insulin Receptor Substrates in Patients of Chronic Hepatitis C Virus with Type-II Diabetes Mellitus

25.

Faqeeha Javed

Frequency of Staphylococcal Cassette Chromosome Mec Type IV and Type V in Clinical Isolates of MRSA

26.

Saba Munir

Molecular Detection of Isoniazid, Rifampin,, Ethambutol resistance of Mycobacterium Tuberculosis and Mycobacterium Bovis in Multidrug resistance tuberculosis patients. (Saba Munir)

27.

Gulashan Ara

A genetic Association Study Based on Analysis of SNP-560 C>T on T-Cell Receptor (TCR) Gene in Patients of IgA Nephropathy (IgAN)

28.

Fatima Shabbir

1Expression Analysis of Tumor Necrosis Factor Alpha (TNF-alpha) and Nuclear Factor Kappa alpha (NFk-alpha) in Patients of Chronic Hepatitis C Virus of Genotypes 3a

29.

Sobia Rizwan

Genetic polymorphism in FTO gene in polycystic ovary syndrome patients

30.

Ghulam Rasool

Comparison of Different Staining Techniques in the Identification of Acid Fast Bacilli in Tuberculous Lymph Node Tissue

31.

Hajra Azhar

Vaginal Carriage of K1 Escherichia Coli during Third Trimester of Pregnancy

32.

Raima Rehman

To Assess Microbiological Quality of Ready to Eat Salads available at different Outlets in Lahore

33.

Faiza Yasmeen

Effect of CYP2C9 Polymorphism in Warfarin Therapy Patients

34.

Aisha Majeed

Soluble Serum Transferrin Receptor (sTfR) Level in Hemodialysis Patients

35.

Muhammad Jawad

Hepcidin Levels in Multi Transfused beta Thalassemia Major Patients

36.

Sana Qayyum Khan

Correlation of Parathyroid Hormone and Magnesium with Vitamin D Deficiency

37.

Hina Mohiuddin

Association of Serum Ascites Albumin Gradient (SAAG) with Causes of Ascites in Hemodialysis Patients

38.

Muqaddas Riaz

Determination of Anti Thyroid Antibodies in Systemic Lupus Erythematosus Patients

39.

Sehrish Kanwal

Exploitation of Standard Modified Hodge Test for the Detection of Extended Spectrum Beta Lactamase Production

40.

Nabila

Relationship Between the Susceptibility of Typhoidal Salmonellae to Ciprofloxcin, Ofloxacin and their Respective Susceptibility to Nalidixic Acid

41.

Saira Munir

In vitro antimycobacterial activity of Pakistani beri honey using MGIT 960

42.

Hafeez Ullah

Circadian Clock Gene Per2 Mutations in Chronic Lymphocytic Leukemia

43.

Warda Hussain

Reference Ranges of Trace Elements (Fe, Zn & Cu) in Adult Population (20- 29 years) of Lahore

44.

Fauzia Sadiq

Ghrelin Levels in Obese Children of Type 2 Diabetic Parents and its Correlation with Risk Parameters of Metabolic Syndrome

45.

Muhammad Atif

Correlation of Glycated Hemoglobin with Zinc and Magnesium Levels in Patients with Type 2 Diabetes Mellitus

46.

Kanwal Azhar

Knowledge and Attitude Regarding Quality Assurance and its Association with Practice among Medical Lab Technologists working in Laboratories of Lahore

47.

Mustafa Munawar

Phenotype and Genotype Characterization of Eunuchs in Lahore

48.

Tauqeer Ali Butt

Assessment of Thyroid Dysfunction in Children with Celiac Disease

49.

Fakhar-un-Nissa

Association of Serum Levels of Zinc and Magnesium with Increased Levels of Glycated Hemoglobin in Patients with Type 2 Diabetes Mellitus

50.

Mr Sarwar Abbas

Determination of CRP and IL-6 in HCV positive and HCV Negative Patients of Chronic Renal Failure on Dialysis

51.

Sara Karim

Determination of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients

52.

Maria Arif

Frequency of Anti Netrophil Cytoplasmic Antibody and Anti Glomerular Basement Membrane Antibody in Glomerlonephritis Patients

53.

Muhammad Waqas Anjum

Comparison of Different Methods for GFR Calculation in Pre-Dialysis Patients

54.

Sundas Fatima

Assessment of Zinc and Copper in Nephrotic Syndrome

55.

Sumaira Farooqi

Assessment of Aluminium, Zinc and Copper in Dialysis Patients

56.

Samra Shaukat

Comparison of Alpha Fetoprotein in Hepatitis C Positive Patients of Liver Cirrhosis with and without Hepatocellular Carcinoma

57.

Farzana Yasmeen

Comparison of Cation Exchange HPLC with Boronate Affinity Chromatography for Determination of HbA1c(Ms. Farzana Yasmeen).

58.

Syeda Aneela

Metallo Beta Lactamase Producing Pseudomonas Aeruginosa Potent Enemy

59.

Kanwal Rauf

Susceptibility Pattern Of Clinical Isolates of Salmonella Typhi against Ethanolic Extract of Garlic

60.

Sidra Shan

Bacteriological Status of Drinking Water from 100 Families of Lahore by Membrane Filtration Technique

61.

Samra Asghar

In Vitro Antibacterial Activity of Crude Leaf Extract of Mango (Mangifera Indica ) on Salmonella Typhi

62.

M. Usman Qamar

Prevelance, Biotyping and Susceptibility Pattern of Coagulase Negative Staphylococci Isolated from cases of Neonatal Septicaemia in a Tertiary Care Hospital

63.

Amber Ilyas

Levels of Antiphopholipid Antibodies in Female with Recurrent Abortions

64.

Muhammad Mahtab Aslam

Evaluation of Platelet Dysfunction in Relation to Hematocrit in Patients with Uremia

65.

Khursheed Javaid

CD4 and CD8 Ratio in Pleural Effusion of T.B and non T.B patients.

66.

Shahid Hussain

Level of Interferon Gamma in Blood of T.B and non T.B patients.

67.

Muhammad Absar

Comparison of Conventional Most Probable Number (MPN) With Standard Membrane Filtration Technique for the Bacteriological Analysis of Drinking Water.

68.

Mr. Faisal Nadeem

Evaluation of Antimycobacterial Activity of Allium Sativum (Garlic Oil) Against 50 Strains of MDR-TB.

69.

Muhammad Ikram Ullah

Anti-Typhoid Activity of Gatifloxacin as Compared to Other Anti Typhoid Fluroquinolones Marketed in Pakistan.

70.

Mr. Muhammad Arshad

Frequency of Extended Spectrum Beta Lactamase Enzymes in Clinical Isolates of Enterobacteriaceae

71.

Muhammad Yasir

Frequency of Carbapenemases in Enterobacteriaceae Isolated from Diagnosed Cases of Nosocomial Blood Stream Infections.

72.

Muhammad Bilal

Significance of Homocysteine in Patients of Dialysis

73.

Shabbir Hussain

Biochemical Evaluation of Erectile Dysfunction in Patients on Dialysis.

74.

Nadia Rasheed

Assessment of Thyroid Dysfunction in Down Syndrome Patients.

75.

Tanveer Ahmed

Lead Exposure in Children Living around Automobile and Battery Repair Workshop.

International Collaborations

1. Prof. Dr. med. Christian Hubner

Head Institute of Human Genetics Functional Genomics

Head Institute of Instituts fur Humangenetik
University Klinikum
Friedrich Schiller University Jena
Germany
[email protected]

2. Prof. Dr. med. Martin Wabitsch

Head of the Division of Padiatric Endocrinology and Diabetes
Ulm University Medical Center
Department of Pediatrics and Adolescent Medicine
Eythstr. 24
89075 Ulm, Germany
e-mail: [email protected]

3. Azeez Butali, DDS, Ph.D. FICD

Professor of Craniofacial Genetics
Member, Smile Train Research and Innovations Advisory Committee
Member, American Society for Human Genetics Nominating Committee
2182 ML
The University of Iowa, College of Dentistry
Iowa City, IA 52242 USA